Pediatric B-Cell Lymphoma With Lymphoblastic Morphology, TdT Expression, MYC Rearrangement, and Features Overlapping With Burkitt Lymphoma

Pediatr Blood Cancer. 2016 May;63(5):938-40. doi: 10.1002/pbc.25907. Epub 2016 Jan 19.

Abstract

Burkitt lymphoma (BL) and B-lymphoblastic lymphoma are subtypes of pediatric non-Hodgkin lymphoma with different presenting features, treatment, and outcomes. This case report documents a 5-year-old female who presented with B-cell lymphoma with lymphoblastic morphology, terminal deoxynucleotidyl transferase expression, MYC rearrangement, and features overlapping with BL. Genomic microarray analysis identified a gain on the long arm of chromosome 1 without other definitive changes. She was treated according to a BL protocol and remains in remission 16-months after initial diagnosis.

Keywords: B-lymphoblastic lymphoma; Burkitt lymphoma; MYC rearrangement.

Publication types

  • Case Reports

MeSH terms

  • Burkitt Lymphoma* / drug therapy
  • Burkitt Lymphoma* / enzymology
  • Burkitt Lymphoma* / genetics
  • Burkitt Lymphoma* / pathology
  • Child, Preschool
  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 1 / genetics*
  • Chromosomes, Human, Pair 1 / metabolism
  • DNA Nucleotidylexotransferase / biosynthesis*
  • DNA Nucleotidylexotransferase / genetics
  • Female
  • Gene Rearrangement*
  • Humans
  • Lymphoma, B-Cell* / drug therapy
  • Lymphoma, B-Cell* / enzymology
  • Lymphoma, B-Cell* / genetics
  • Lymphoma, B-Cell* / pathology
  • Proto-Oncogene Proteins c-myc / genetics*
  • Proto-Oncogene Proteins c-myc / metabolism

Substances

  • MYC protein, human
  • Proto-Oncogene Proteins c-myc
  • DNA Nucleotidylexotransferase