The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer

Mitsuru Okuno; Seiji Adachi; Osamu Kozawa; Masahito Shimizu; Ichiro Yasuda

doi:10.3390/ijms17010137

The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer

Int J Mol Sci. 2016 Jan 21;17(1):137. doi: 10.3390/ijms17010137.

Authors

Mitsuru Okuno¹, Seiji Adachi², Osamu Kozawa³, Masahito Shimizu⁴, Ichiro Yasuda⁵

Affiliations

¹ Department of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. mkobdkl@yahoo.co.jp.
² Department of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. seijiadachi0123@gmail.com.
³ Department of Pharmacology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. okozawa@gifu-u.ac.jp.
⁴ Department of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. shimim-gif@umin.ac.jp.
⁵ Department of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. yasudaich@gmail.com.

Abstract

Pancreatic cancer is one of most aggressive forms of cancer. After clinical detection it exhibits fast metastatic growth. Heat shock protein 27 (HSP27; HSPB1) has been characterized as a molecular chaperone which modifies the structures and functions of other proteins in cells when they are exposed to various stresses, such as chemotherapy. While the administration of gemcitabine, an anti-tumor drug, has been the standard treatment for patients with advanced pancreatic cancer, accumulating evidence shows that HSP27 plays a key role in the chemosensitivity to gemcitabine. In addition, phosphorylated HSP27 induced by gemcitabine has been associated with the inhibition of pancreatic cancer cell growth. In this review, we summarize the role of phosphorylated HSP27, as well as HSP27, in the regulation of chemosensitivity in pancreatic cancer.

Keywords: HSP27; chemosensitivity; pancreatic cancer; phosphorylated HSP27; prognosis.

Publication types

Review

MeSH terms

Antimetabolites, Antineoplastic / therapeutic use
Biomarkers, Tumor / genetics*
Biomarkers, Tumor / metabolism
Cell Line, Tumor
Deoxycytidine / analogs & derivatives
Deoxycytidine / therapeutic use
Drug Resistance, Neoplasm / genetics
Gemcitabine
Gene Expression Regulation, Neoplastic*
HSP27 Heat-Shock Proteins / genetics*
HSP27 Heat-Shock Proteins / metabolism
Heat-Shock Proteins
Humans
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / metabolism
Molecular Chaperones
Pancreatic Neoplasms / diagnosis*
Pancreatic Neoplasms / genetics*
Pancreatic Neoplasms / metabolism
Pancreatic Neoplasms / pathology
Phosphorylation
Prognosis
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
p38 Mitogen-Activated Protein Kinases / genetics
p38 Mitogen-Activated Protein Kinases / metabolism

Substances

Antimetabolites, Antineoplastic
Biomarkers, Tumor
HSP27 Heat-Shock Proteins
HSPB1 protein, human
Heat-Shock Proteins
Intracellular Signaling Peptides and Proteins
Molecular Chaperones
Deoxycytidine
MAP-kinase-activated kinase 2
Protein Serine-Threonine Kinases
p38 Mitogen-Activated Protein Kinases
Gemcitabine