BCR engagement in CLL: when translation goes wrong

Blood. 2016 Jan 28;127(4):378-80. doi: 10.1182/blood-2015-11-678623.

Abstract

In this issue of Blood, Yeomans et al identify MYC as an important target for translational regulation in chronic lymphocytic leukemia (CLL) cells after B-cell receptor (BCR) stimulation and show that current therapies suppress this induction.

Publication types

  • Comment

MeSH terms

  • Gene Expression Regulation, Leukemic*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Proto-Oncogene Proteins c-myc / genetics*
  • RNA, Messenger / genetics*
  • Receptors, Antigen, B-Cell / immunology*

Substances

  • Proto-Oncogene Proteins c-myc
  • RNA, Messenger
  • Receptors, Antigen, B-Cell