Novel molecular mechanisms and regeneration therapy for heart failure

J Mol Cell Cardiol. 2016 Mar:92:46-51. doi: 10.1016/j.yjmcc.2016.01.028. Epub 2016 Jan 29.

Abstract

Heart failure (HF) is one of the leading causes of mortality in the world. Various molecular mechanisms have been proposed for HF, but its precise mechanisms are still largely unknown. In this review, summarizing the "President's Distinguished Lecture Award" of XX World Congress of International Society for Heart Research 2010 in Kyoto, Japan, we introduce recent our studies on HF, including 1) p53-induced suppression of Hif-1-induced angiogenesis as a novel mechanism of HF, 2) angiogenesis as a potential therapeutic strategy for HF, and 3) IGFBP-4 as a novel factor for cardiomyogenesis by inhibiting canonical Wnt signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Heart Failure / genetics*
  • Heart Failure / pathology
  • Heart Failure / therapy*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics
  • Insulin-Like Growth Factor Binding Protein 4 / genetics
  • Muscle Development / genetics
  • Neovascularization, Pathologic / genetics*
  • Neovascularization, Pathologic / pathology
  • Neovascularization, Pathologic / therapy*
  • Regeneration
  • Tumor Suppressor Protein p53 / genetics

Substances

  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Insulin-Like Growth Factor Binding Protein 4
  • TP53 protein, human
  • Tumor Suppressor Protein p53