Immunotherapy and Oncogenic Pathways: The PTEN Connection

Cancer Discov. 2016 Feb;6(2):128-9. doi: 10.1158/2159-8290.CD-15-1501.

Abstract

Peng and colleagues describe the effects of PTEN inactivation on antitumor immunity and response to immune checkpoint blockade in melanoma. These results shed light on the intricate interplay between oncogenic pathways and antitumor immune response.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antibodies, Monoclonal / pharmacology
  • Antibodies, Monoclonal / therapeutic use*
  • Humans
  • Immunotherapy / methods
  • Melanoma / drug therapy*
  • Melanoma / genetics
  • Melanoma / immunology
  • Mutation
  • Neoplasm Metastasis
  • PTEN Phosphohydrolase / genetics*
  • PTEN Phosphohydrolase / metabolism
  • Signal Transduction / drug effects
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal
  • PTEN Phosphohydrolase
  • PTEN protein, human