Abstract
Peng and colleagues describe the effects of PTEN inactivation on antitumor immunity and response to immune checkpoint blockade in melanoma. These results shed light on the intricate interplay between oncogenic pathways and antitumor immune response.
©2016 American Association for Cancer Research.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Antibodies, Monoclonal / pharmacology
-
Antibodies, Monoclonal / therapeutic use*
-
Humans
-
Immunotherapy / methods
-
Melanoma / drug therapy*
-
Melanoma / genetics
-
Melanoma / immunology
-
Mutation
-
Neoplasm Metastasis
-
PTEN Phosphohydrolase / genetics*
-
PTEN Phosphohydrolase / metabolism
-
Signal Transduction / drug effects
-
Treatment Outcome
Substances
-
Antibodies, Monoclonal
-
PTEN Phosphohydrolase
-
PTEN protein, human