High levels of the c-myc protein in cell lines of Bloom's syndrome origin

N F Sullivan; A E Willis; J P Moore; T Lindahl

High levels of the c-myc protein in cell lines of Bloom's syndrome origin

Oncogene. 1989 Dec;4(12):1509-11.

Authors

N F Sullivan¹, A E Willis, J P Moore, T Lindahl

Affiliation

¹ Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hert, U.K.

PMID: 2687770

Abstract

Lymphoblastoid cell lines derived from cancer prone Bloom's Syndrome patients differ from cell lines representative of several other disorders by exhibiting a constitutive elevation in the level of the c-myc protein. This may be a contributing factor in the strong predisposition to malignancy observed in Bloom's syndrome.

MeSH terms

Bloom Syndrome / enzymology
Bloom Syndrome / genetics*
Cell Line
Enzyme-Linked Immunosorbent Assay
Humans
Protein-Tyrosine Kinases / analysis*
Proto-Oncogene Proteins / analysis*
Proto-Oncogene Proteins c-myc
Proto-Oncogenes*

Substances

Proto-Oncogene Proteins
Proto-Oncogene Proteins c-myc
Protein-Tyrosine Kinases