Association of ICAM-1 (K469E) and MCP-1 -2518 A>G gene polymorphism with brain abscess

J Neuroimmunol. 2016 Mar 15:292:102-7. doi: 10.1016/j.jneuroim.2016.01.021. Epub 2016 Feb 2.

Abstract

Brain abscess develops in response to a parenchymal infection. Intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play vital role in central nervous system (CNS) diseases. We studied ICAM-1 (K469E) and MCP-1 (-2518 A>G) polymorphisms among brain abscess patients. The genotypic distributions of ICAM-1 (K469E) and MCP-1 (-2518 A>G) were significantly different between patients and controls. Further, patient with predisposing factors, and also with culture result, we found significant association. The study revealed that the polymorphisms of these molecules lead to increased production, which appears to be a risk for the development of brain abscess.

Keywords: Brain abscess; ICAM-1; MCP-1; Polymorphisms; Serum level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brain Abscess / genetics*
  • Chemokine CCL2 / genetics*
  • Child
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Intercellular Adhesion Molecule-1 / genetics*
  • Male
  • Polymorphism, Restriction Fragment Length / genetics*
  • Young Adult

Substances

  • CCL2 protein, human
  • Chemokine CCL2
  • Intercellular Adhesion Molecule-1