Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication

Gerard Karsenty; Eric N Olson

doi:10.1016/j.cell.2016.02.043

Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication

Cell. 2016 Mar 10;164(6):1248-1256. doi: 10.1016/j.cell.2016.02.043.

Authors

Gerard Karsenty¹, Eric N Olson²

Affiliations

¹ Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: gk2172@cumc.columbia.edu.
² Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Most physiological functions originate with the communication between organs. Mouse genetics has revived this holistic view of physiology through the identification of inter-organ communications that are unanticipated, functionally important, and would have been difficult to uncover otherwise. This Review highlights this point by showing how two tissues usually not seen as endocrine ones, bone and striated muscles, influence several physiological processes in a significant manner.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bone and Bones / physiology*
Cytokines / metabolism
Energy Metabolism
Humans
Mice
Muscle, Skeletal / physiology*
Osteocalcin
Phosphates / metabolism

Substances

Cytokines
Phosphates
Osteocalcin

Abstract

Publication types

MeSH terms

Substances

Grants and funding