Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways

Bioorg Med Chem. 2016 Apr 15;24(8):1927-35. doi: 10.1016/j.bmc.2016.03.024. Epub 2016 Mar 16.

Abstract

This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375.

Keywords: Anti-inflammatory; Autophagy; COX-2; Curcumin analog; DM1; Edema; Peritonitis; iNOS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Autophagy / drug effects*
  • Carrageenan
  • Cells, Cultured
  • Curcumin / analogs & derivatives*
  • Curcumin / chemistry
  • Curcumin / pharmacology*
  • Cyclooxygenase 2 / genetics*
  • Dose-Response Relationship, Drug
  • Edema / chemically induced
  • Edema / drug therapy*
  • Gene Expression Profiling
  • Gene Expression Regulation, Enzymologic / drug effects*
  • Humans
  • Male
  • Mice
  • Molecular Structure
  • Nitric Oxide / biosynthesis
  • Nitric Oxide Synthase Type II / genetics*
  • Structure-Activity Relationship

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Nitric Oxide
  • Carrageenan
  • Nitric Oxide Synthase Type II
  • Nos2 protein, mouse
  • Ptgs2 protein, mouse
  • Cyclooxygenase 2
  • Curcumin