Actin'g against the Ball and Chain

Jasmine V G Abella; Michael Way

doi:10.1016/j.devcel.2016.03.014

Actin'g against the Ball and Chain

Dev Cell. 2016 Apr 4;37(1):11-12. doi: 10.1016/j.devcel.2016.03.014.

Authors

Jasmine V G Abella¹, Michael Way²

Affiliations

¹ Cellular Signalling and Cytoskeletal Function Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
² Cellular Signalling and Cytoskeletal Function Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address: michael.way@crick.ac.uk.

PMID: 27046828
DOI: 10.1016/j.devcel.2016.03.014

Abstract

Spinocerebellar ataxia type 13 is a rare autosomal-dominant neurodegenerative disease induced by mutations in the voltage-dependent Kv3.3 potassium channel. Recently in Cell, Zhang et al. (2016) provide new insights into how Arp2/3-dependent actin polymerization modulates both Kv3.3 activity and its ability to stimulate actin polymerization via Hax-1.

Publication types

Comment

MeSH terms

Actins / genetics*
Humans
Mutation
Shaw Potassium Channels*
Spinocerebellar Degenerations

Substances

Actins
Shaw Potassium Channels