Abstract
The mechanistic basis for the biological properties of Morus alba flavonoid extract (MFE) and chemotherapy drug of doxorubicin on human colon cancer HT-29 cell line death are unknown. The effect of doxorubicin and flavonoid extract on colon cancer HT-29 cell line death and identification of APC gene expression and PARP concentration of HT-29 cell line were investigated. The results showed that flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line. MFE and doxorubicin exert a cytotoxic effect on human colon cancer HT-29 cell line by probably promoting or induction of apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects
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Colon / drug effects
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Colon / metabolism
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Colon / pathology
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / genetics
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Colonic Neoplasms / pathology
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Doxorubicin / chemistry
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Doxorubicin / pharmacology*
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Gene Expression Regulation, Neoplastic / drug effects
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Genes, APC / drug effects
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HT29 Cells
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Humans
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Morus / chemistry*
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Plant Extracts
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Plant Leaves / chemistry
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Poly(ADP-ribose) Polymerases / analysis
Substances
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Antibiotics, Antineoplastic
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Antineoplastic Agents, Phytogenic
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Flavonoids
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Plant Extracts
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Doxorubicin
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Poly(ADP-ribose) Polymerases