Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

A P Palumbo; M Boccadoro; S Battaglio; P Corradini; B Giovinazzo; G Avanzi; G Ponzio

doi:10.1016/0165-4608(89)90232-x

Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

Cancer Genet Cytogenet. 1989 May;39(1):77-80. doi: 10.1016/0165-4608(89)90232-x.

Authors

A P Palumbo¹, M Boccadoro, S Battaglio, P Corradini, B Giovinazzo, G Avanzi, G Ponzio

Affiliation

¹ Dipartimento di Medicina e Oncologia Sperimentale, Universita' di Torino, Italy.

PMID: 2731151
DOI: 10.1016/0165-4608(89)90232-x

Abstract

We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Blotting, Southern
Chromosomes, Human, Pair 15*
Chromosomes, Human, Pair 22*
Chromosomes, Human, Pair 9*
Female
Humans
Karyotyping
Philadelphia Chromosome*
Thrombocythemia, Essential / genetics*
Translocation, Genetic*