Association of IL-10 (-819T/C, -592A/C and -1082A/G) and IL-6 -174G/C gene polymorphism and the risk of pneumonia-induced sepsis

Biomarkers. 2017 Mar;22(2):106-112. doi: 10.1080/1354750X.2016.1210677. Epub 2016 Aug 5.

Abstract

Context: Association between inherited variants and the risks of sepsis is controversial.

Objective: To evaluate the risk of pneumonia-induced sepsis by examining its linkage with polymorphisms of IL-6 and IL-10.

Materials and methods: Samples were obtained from 188 pneumonia-induced sepsis patients, 162 pneumonia patients and 200 healthy controls.

Results: Subjects with IL-10 -1082 AA genotypes and IL-6 -174 CC genotype had a higher risk of sepsis and increased mRNA levels.

Conclusion: The variants of IL-10 -1082 A allele and IL-6 -174 C allele contributed to an increased risk of pneumonia-induced sepsis.

Keywords: IL-10; IL-6; Single-nuclear polymorphism; inflammation; mRNA; sepsis.

MeSH terms

  • Adult
  • Case-Control Studies
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin-10 / genetics*
  • Interleukin-6 / genetics*
  • Middle Aged
  • Pneumonia / complications*
  • Polymorphism, Single Nucleotide*
  • Risk
  • Sepsis / etiology*
  • Sepsis / genetics

Substances

  • IL10 protein, human
  • IL6 protein, human
  • Interleukin-6
  • Interleukin-10