Thrombolytic treatment in a patient with antiphospholipid syndrome : APS developing renal infarction

Z Rheumatol. 2016 Oct;75(8):838-841. doi: 10.1007/s00393-016-0154-7.

Abstract

Antiphospholipid syndrome (APS), a leading entity in acquired thrombophilia, is characterized by recurrent thrombosis, morbidity in pregnancy and presence of antiphospholipid antibodies (APA). Although the etiopathogenesis is unclear, APA against negatively charged phospholipids and phospholipid-protein complexes are held responsible for the clinical picture. In case of acute thrombosis due to APS, thrombolytic therapy is not a commonly administered treatment option. Here, we present a case with acute thrombosis in the left renal artery showing partial response to thrombolytic therapy.

Keywords: Antiphospholipid syndrome; Renal infarction; Thrombolytic treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiphospholipid Syndrome / complications*
  • Antiphospholipid Syndrome / diagnosis
  • Antiphospholipid Syndrome / drug therapy*
  • Diagnosis, Differential
  • Female
  • Fibrinolytic Agents / administration & dosage*
  • Humans
  • Infarction / diagnosis
  • Infarction / etiology*
  • Infarction / prevention & control*
  • Kidney / blood supply*
  • Treatment Outcome

Substances

  • Fibrinolytic Agents

Supplementary concepts

  • Familial antiphospholipid syndrome