Curcumin inhibits angiogenesis by up-regulation of microRNA-1275 and microRNA-1246: a promising therapy for treatment of corneal neovascularization

Cell Prolif. 2016 Dec;49(6):751-762. doi: 10.1111/cpr.12289. Epub 2016 Sep 14.

Abstract

Objective: Curcumin (capable of inhibiting angiogenic growth of human umbilical vein endothelial cells [HUVECs]), can be employed in vitro as a model of pathogenesis of corneal neovascularization (CRNV). The aim of this study was to explore regulatory mechanisms of microRNA (miR) levels after curcumin treatment.

Materials and methods: Expression profiles of miRs in curcumin-treated HUVECs were investigated by miR microassay. Specific mimics and inhibitors of miR-1275 or miR-1246 were transfected into HUVECs. Then, their target genes, vascular endothelial growth factor B (VEGFB) and nuclear transcription factor kappa B acting protein (NKAP) were detected by quantitative real-time PCR, Western blotting assay or immunofluorescence assay. Cell proliferation and cell cycle parameters were measured with the help of CCK-8 assay and flow cytometry.

Results: MiR-1275 and miR-1246 expression levels were up-regulated by curcumin. Administration of the specific mimics and inhibitors of the two miRs led to significant changes in expression of VEGFB and NKAP as well as the indicators related to angiogenesis. Anti-angiogenic effect of curcumin depended on expression patterns of the two miRs in that inhibition of either miR interfered with the effect of curcumin. Furthermore, overexpression of NKAP interrupted effects of curcumin on the cells.

Conclusion: Collectively, our findings demonstrate that curcumin inhibited HUVEC proliferation by up-regulation of miR-1275 and miR-1246.

MeSH terms

  • Angiogenesis Inhibitors / pharmacology*
  • Co-Repressor Proteins / genetics
  • Corneal Neovascularization / drug therapy*
  • Corneal Neovascularization / genetics
  • Corneal Neovascularization / pathology
  • Curcumin / pharmacology*
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • MicroRNAs / genetics*
  • Neovascularization, Pathologic / drug therapy*
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / pathology
  • Nuclear Proteins / genetics
  • Repressor Proteins
  • Up-Regulation / drug effects*

Substances

  • Angiogenesis Inhibitors
  • Co-Repressor Proteins
  • MIRN1246 microRNA, human
  • MIRN1275 microRNA, human
  • MicroRNAs
  • NKAP protein, human
  • Nuclear Proteins
  • Repressor Proteins
  • Curcumin