Release of lysosomal hydrolases (including phospholipase A), increase in content of lysophosphatidyl choline and cardiolipin and decrease in content of phosphatidyl choline and phosphatidyl ethanolamine, activation of lipid peroxidation, inhibition of the cell antioxidant system, inhibition of tricarboxylic acid cycle enzymes and of beta-hydroxybutyrate dehydrogenase in mitochondria were detected in hepatocytes of rats after acute poisoning with necrosogenic toxins D-galactosamine, allyl alcohol and apamide. Hydrazine and ethanol caused an extensive steatosis of liver tissue parenchyma, decreased moderately the activity of mitochondrial enzymes, stimulated lipid peroxidation without impairment of antiradical activity of the lipids, contributed to accumulation of cardiolipin and to a decrease in phosphatidyl choline content.