Autoimmune Blistering Diseases in the Elderly: Clinical Presentations and Management

Minhee Kim; Luca Borradori; Dédée F Murrell

doi:10.1007/s40266-016-0402-1

Autoimmune Blistering Diseases in the Elderly: Clinical Presentations and Management

Drugs Aging. 2016 Oct;33(10):711-723. doi: 10.1007/s40266-016-0402-1.

Authors

Minhee Kim^{1

2}, Luca Borradori³, Dédée F Murrell^{4

5}

Affiliations

¹ Department of Dermatology, St. George Hospital, Gray St, Kogarah, Sydney, 2217, NSW, Australia.
² University of New South Wales, Sydney, NSW, Australia.
³ Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
⁴ Department of Dermatology, St. George Hospital, Gray St, Kogarah, Sydney, 2217, NSW, Australia. d.murrell@unsw.edu.au.
⁵ University of New South Wales, Sydney, NSW, Australia. d.murrell@unsw.edu.au.

PMID: 27738963
DOI: 10.1007/s40266-016-0402-1

Abstract

Elderly patients are more susceptible to the development of autoimmune blistering disorders such as bullous pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, and paraneoplastic pemphigus. This article focuses on the clinical aspects of the aforementioned autoimmune blistering diseases and highlights the important factors involved in treating elderly patients. It is essential for clinicians to offer individualized treatment plans for these patients to optimize outcomes, as elderly patients often have multiple co-morbidities, polypharmacy, and suboptimal socioeconomic status that can adversely influence adequate compliance.

Publication types

Review

MeSH terms

Aged
Aging* / drug effects
Aging* / immunology
Antibodies, Monoclonal / administration & dosage
Antibodies, Monoclonal / adverse effects
Antibodies, Monoclonal / therapeutic use*
Autoimmune Diseases* / diagnosis
Autoimmune Diseases* / drug therapy
Autoimmune Diseases* / epidemiology
Comorbidity
Epidermolysis Bullosa Acquisita / diagnosis
Epidermolysis Bullosa Acquisita / drug therapy
Epidermolysis Bullosa Acquisita / epidemiology
Glucocorticoids / administration & dosage
Glucocorticoids / adverse effects
Glucocorticoids / therapeutic use*
Humans
Immunosuppressive Agents / administration & dosage
Immunosuppressive Agents / adverse effects
Immunosuppressive Agents / therapeutic use*
Paraneoplastic Syndromes / diagnosis
Paraneoplastic Syndromes / drug therapy
Paraneoplastic Syndromes / epidemiology
Paraneoplastic Syndromes / surgery
Pemphigoid, Benign Mucous Membrane / diagnosis
Pemphigoid, Benign Mucous Membrane / drug therapy
Pemphigoid, Benign Mucous Membrane / epidemiology
Pemphigoid, Bullous / diagnosis
Pemphigoid, Bullous / drug therapy
Pemphigoid, Bullous / epidemiology
Pemphigus / diagnosis
Pemphigus / drug therapy
Pemphigus / epidemiology
Skin Diseases, Vesiculobullous* / diagnosis
Skin Diseases, Vesiculobullous* / drug therapy
Skin Diseases, Vesiculobullous* / epidemiology

Substances

Antibodies, Monoclonal
Glucocorticoids
Immunosuppressive Agents