Chronic Myelogenous Leukemia Presenting as a Secondary Malignancy After BCR-ABL1-negative B-lymphoblastic Leukemia/Lymphoma in a Pediatric Patient

Pediatr Dev Pathol. 2017 Jan-Feb;20(1):58-62. doi: 10.1177/1093526616671047.

Abstract

Chronic myelogenous leukemia, BCR-ABL1 positive (CML) is a rare myeloproliferative neoplasm in children and presents even less often as a secondary malignancy in the pediatric population. Below, we report a patient with Philadelphia-negative B-lymphoblastic leukemia/lymphoma, who developed CML several years after achieving complete remission, and summarize the existing literature on the clinical and pathologic features of CML as a secondary pediatric malignancy.

Keywords: BCR-ABL1; chronic myelogenous leukemia; cytogenetics; flow cytometry; lymphoblastic leukemia/lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Child
  • Female
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis*
  • Neoplasms, Second Primary / diagnosis*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / diagnosis
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / metabolism
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / therapy
  • Proto-Oncogene Proteins c-abl / metabolism
  • Proto-Oncogene Proteins c-bcr / metabolism

Substances

  • Biomarkers, Tumor
  • ABL1 protein, human
  • Proto-Oncogene Proteins c-abl
  • BCR protein, human
  • Proto-Oncogene Proteins c-bcr