Abstract
Proviral activation of the int-2 gene is a frequent occurrence in mammary carcinomas induced by mouse mammary tumor virus (MMTV). Here, we have examined the human homolog of int-2 in 110 primary breast cancer DNAs. The locus was amplified 2- to 15-fold in 18 of the tumor DNA samples. Amplification of int-2 has a highly significant association (P less than 2 X 10(-6] with tumors from patients who subsequently developed a local recurrence of the disease or a distal metastasis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism
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Carcinoma, Intraductal, Noninfiltrating / genetics
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Carcinoma, Intraductal, Noninfiltrating / metabolism
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Cloning, Molecular
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Female
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Gene Amplification*
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Humans
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Mice
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins / isolation & purification
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Proto-Oncogenes
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Wnt Proteins
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Zebrafish Proteins*
Substances
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Proto-Oncogene Proteins
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Wnt Proteins
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Zebrafish Proteins