Abstract
The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small interfering RNA, as well as a growing number of additional small RNAs derived from various sources. Emerging evidence demonstrates that Dicer's endonuclease role extends beyond the generation of small RNAs; it is also involved in processing additional endogenous and exogenous substrates, and is becoming increasingly implicated in regulating a variety of other cellular processes, outside of its endonuclease function. This review will describe the canonical and newly identified functions of Dicer.
Keywords:
endoribonuclease Dicer; microRNA; small interfering RNA; viral small RNA.
© 2017 The Author(s).
Publication types
-
Review
-
Research Support, N.I.H., Extramural
MeSH terms
-
Animals
-
Apoptosis
-
DEAD-box RNA Helicases / chemistry
-
DEAD-box RNA Helicases / genetics
-
DEAD-box RNA Helicases / metabolism*
-
Exosomes / enzymology
-
Exosomes / metabolism
-
Gene Expression Regulation*
-
Host-Pathogen Interactions
-
Humans
-
MicroRNAs / metabolism
-
Models, Molecular*
-
Phylogeny
-
Protein Interaction Domains and Motifs
-
RNA Interference*
-
RNA Stability*
-
RNA, Small Cytoplasmic / metabolism*
-
RNA, Small Interfering / metabolism
-
RNA, Small Nucleolar / metabolism*
-
RNA, Transfer / metabolism
-
RNA, Viral / metabolism
-
Ribonuclease III / chemistry
-
Ribonuclease III / genetics
-
Ribonuclease III / metabolism*
-
Substrate Specificity
-
Trinucleotide Repeats
Substances
-
MicroRNAs
-
RNA, Small Cytoplasmic
-
RNA, Small Interfering
-
RNA, Small Nucleolar
-
RNA, Viral
-
RNA, Transfer
-
DICER1 protein, human
-
Ribonuclease III
-
DEAD-box RNA Helicases