Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma

Oncogene. 1988 Nov;3(5):537-40.

Abstract

Transforming activity was detected in a hepatocellular carcinoma (HCC) carrying four integrated hepatitis B virus (HBV) DNA. This transforming gene was identified as hst-1, that lies in chromosome 11, band q13.3. One of the integrated HBV DNAs was found to lie close to the hst-1, and the hst-1 and the integrated HBV DNA were found to be co-amplified. The region of the amplification was limited. A model has been proposed that correlates the viral integration, amplification and activation of an oncogene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Hepatocellular / genetics*
  • Cell Transformation, Neoplastic*
  • Chromosome Banding
  • Chromosomes, Human, Pair 11*
  • DNA, Neoplasm / genetics
  • DNA, Viral / genetics*
  • Gene Amplification*
  • Genes, Viral*
  • Hepatitis B virus / genetics*
  • Humans
  • Liver Neoplasms / genetics*
  • Oncogenes*

Substances

  • DNA, Neoplasm
  • DNA, Viral