The Role of TLR4, TNF-α and IL-1β in Type 2 Diabetes Mellitus Development within a North Indian Population

Ann Hum Genet. 2017 Jul;81(4):141-146. doi: 10.1111/ahg.12197.

Abstract

This study investigated the role of IL-1β-511 (rs16944), TLR4-896 (rs4986790) and TNF-α-308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population. Four hundred fourteen participants (204 T2DM patients and 210 nondiabetic controls) were genotyped for IL-1β-511, TLR4-896 and TNF-α-308 loci. The C allele of IL-1β-511 was shown to increase T2DM susceptibility by 75% (OR: 1.75 [CI 1.32-2.33]). Having two parents affected by T2DM increased susceptibility by 5.7 times (OR: 5.693 [CI 1.431-22.648]). In this study, we have demonstrated a conclusive association with IL-1β-511 locus and IL-1β-511-TLR4-896 diplotype (CC-AA) and T2DM, which warrants further comprehensive analyses in larger cohorts.

Keywords: IL-1β-511; Inflammatory gene polymorphisms; North Indian population; TLR4 896; TNF-α-308; Type 2 diabetes mellitus.

MeSH terms

  • Aged
  • Diabetes Mellitus, Type 2 / genetics*
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • India
  • Interleukin-1beta / genetics*
  • Logistic Models
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Toll-Like Receptor 4 / genetics*
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • Interleukin-1beta
  • TLR4 protein, human
  • Toll-Like Receptor 4
  • Tumor Necrosis Factor-alpha