Abstract
Sucrose non-fermenting related kinase (SNRK) is a serine/threonine kinase known to regulate cellular metabolism and adipocyte inflammation. Since alterations in adipocyte metabolism play a role in ovarian cancer metastasis, we investigated the expression of SNRK in benign and malignant human ovarian tissue using immunohistochemistry and qPCR. The number of SNRK positive (+) nuclei is increased in malignant tissue compared to benign tissue (21.03% versus 14.90%, p < .0431). The most strongly stained malignant SNRK+ nuclei were stage 1 compared to stage 2-4 disease. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis.
Keywords:
Cancer biomarkers; Invasion & metastasis; Ovarian cancer.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Biomarkers, Tumor / analysis*
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Biomarkers, Tumor / genetics
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Carcinoma, Ovarian Epithelial
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Female
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Gene Expression Regulation, Enzymologic
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Gene Expression Regulation, Neoplastic
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Humans
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Immunohistochemistry
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Middle Aged
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Neoplasm Grading
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Neoplasm Staging
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Neoplasms, Glandular and Epithelial / enzymology*
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Neoplasms, Glandular and Epithelial / genetics
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Neoplasms, Glandular and Epithelial / secondary
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Neoplasms, Glandular and Epithelial / therapy
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Ovarian Neoplasms / enzymology*
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Ovarian Neoplasms / genetics
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Ovarian Neoplasms / pathology
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Ovarian Neoplasms / therapy
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Protein Serine-Threonine Kinases / analysis*
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Protein Serine-Threonine Kinases / genetics
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RNA, Messenger / genetics
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Real-Time Polymerase Chain Reaction
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Biomarkers, Tumor
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RNA, Messenger
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SNRK protein, human
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Protein Serine-Threonine Kinases