Progress toward resolving the possible linkage of multiple endocrine neoplasia type 2A to haptoglobin and group-specific loci: use of restriction fragment length polymorphisms extends exclusion region

Genet Epidemiol. 1986;3(3):195-200. doi: 10.1002/gepi.1370030306.

Abstract

In an earlier paper, positive but nonsignificant lod scores were found in pair-wise linkage tests between multiple endocrine neoplasia type 2A (MEN-2A) and both the haptoglobin (HP) locus on chromosome 16 and group-specific component (GC) locus on chromosome 4. Recently discovered restriction fragment length polymorphisms for HP and for metallothionein 2 processed pseudogene 1 (MT2P1) near GC have made it possible to carry out a more powerful set of linkage tests with MEN-2A. This paper reports the results of such linkage analyses employing both pair-wise and multipoint tests. Close linkage of HP on chromosome 16 and MEN-2A is excluded. Linkage of MEN-2A on chromosome 4 with GC is excluded on the MT2P1 side of GC in a 7-centimorgan interval around MT2P1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Protein Electrophoresis
  • Chromosome Mapping
  • Chromosomes, Human, 16-18*
  • Chromosomes, Human, 4-5*
  • DNA Restriction Enzymes
  • Genetic Markers*
  • Haptoglobins / genetics*
  • Humans
  • Lod Score
  • Multiple Endocrine Neoplasia / genetics*
  • Polymorphism, Genetic
  • Vitamin D-Binding Protein / genetics*

Substances

  • Genetic Markers
  • Haptoglobins
  • Vitamin D-Binding Protein
  • DNA Restriction Enzymes