Fibrohistiocytic Tumors

Ryan C Romano; Karen J Fritchie

doi:10.1016/j.cll.2017.05.007

Fibrohistiocytic Tumors

Clin Lab Med. 2017 Sep;37(3):603-631. doi: 10.1016/j.cll.2017.05.007. Epub 2017 Jun 15.

Authors

Ryan C Romano¹, Karen J Fritchie²

Affiliations

¹ Department of Dermatology, Mayo Clinic, Gonda 16, 200 First Street Southwest, Rochester, MN 55905, USA.
² Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Hilton 11, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: fritchie.karen@mayo.edu.

PMID: 28802503
DOI: 10.1016/j.cll.2017.05.007

Abstract

Fibrohistiocytic tumors are a diverse group of reactive and neoplastic lesions including xanthoma, fibrous histiocytoma and its variants, solitary xanthogranuloma, dermatofibrosarcoma protuberans, and atypical fibroxanthoma. This article reviews some of the more commonly encountered fibrohistiocytic tumors with an emphasis on clinical presentation, macroscopic and histologic characteristics, molecular/cytogenetic findings where applicable, and differential diagnoses.

Keywords: Dermatofibrosarcoma protuberans; Fibrohistiocytic; Fibrous histiocytoma; Histiocytes; Xanthogranuloma.

Publication types

Review

MeSH terms

Dermatofibrosarcoma / pathology*
Diagnosis, Differential
Histiocytoma, Benign Fibrous / pathology*
Humans
Skin Neoplasms / pathology*
Xanthomatosis / pathology