Abstract
The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA genes.
Keywords:
7SK snRNA; 7SK snRNP; P-TEFb; RNA polymerase II pausing; transcription regulation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatin / genetics
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Chromatin / metabolism
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Humans
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Positive Transcriptional Elongation Factor B / metabolism*
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Promoter Regions, Genetic
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Protein Binding
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RNA Polymerase II / genetics
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RNA Polymerase II / metabolism
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RNA, Small Nuclear / genetics
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RNA, Small Nuclear / metabolism*
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Transcriptional Activation*
Substances
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Chromatin
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RNA, Small Nuclear
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Positive Transcriptional Elongation Factor B
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RNA Polymerase II
Grants and funding
Our work was supported by grants from la Fondation ARC pour la recherche sur le cancer (to SE), l'Agence Nationale de la Recherche (to T.K.).