Abstract
Expression of the c-myc gene was studied by northern blot and slot blot hybridisation in 72 specimens of stage I or II squamous cell carcinoma of the uterine cervix. In 25 of the 72 tumours c-myc proto-oncogene was overexpressed (ie, at levels 4-20 times higher than in normal tissues). Patients whose tumours showed c-myc overexpression had an eight-fold greater incidence of early relapse than the other patients (p = 0.001). The 18-month relapse-free survival rates were, respectively, 49% and 90% for these two groups of patients.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Aged
-
Aged, 80 and over
-
Carcinoma, Squamous Cell / diagnosis*
-
Carcinoma, Squamous Cell / genetics
-
Female
-
Humans
-
Middle Aged
-
Nucleic Acid Hybridization
-
Prognosis
-
Proto-Oncogene Mas
-
Proto-Oncogene Proteins / analysis*
-
Proto-Oncogene Proteins c-myc
-
Proto-Oncogenes*
-
RNA, Neoplasm / analysis
-
Uterine Cervical Neoplasms / diagnosis*
-
Uterine Cervical Neoplasms / genetics
Substances
-
MAS1 protein, human
-
Proto-Oncogene Mas
-
Proto-Oncogene Proteins
-
Proto-Oncogene Proteins c-myc
-
RNA, Neoplasm