Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia

M Smit; E van der Kooij-Meijs; R R Frants; L Havekes; E C Klasen

doi:10.1007/BF00291243

Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia

Hum Genet. 1988 Jan;78(1):90-3. doi: 10.1007/BF00291243.

Authors

M Smit¹, E van der Kooij-Meijs, R R Frants, L Havekes, E C Klasen

Affiliation

¹ Department of Human Genetics, Sylvius Laboratories, Leiden, The Netherlands.

PMID: 2892779
DOI: 10.1007/BF00291243

Abstract

Recently, using an APOE cDNA probe, we discovered an Hpa I restriction fragment length polymorphism (RFLP) that appeared to be strongly associated with the expression of type III hyperlipoproteinemia (Klasen et al. 1987). In the present report it is shown that the same Hpa I RFLP can be revealed with both the APOC1 and APOC2 cDNA probes. This enabled us to localize the polymorphic Hpa I site between the APOE and APOC1 genes and to localize the APOC2 gene approximately 22 kb 3' of the APOC1 pseudogene on chromosome 19.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apolipoproteins / genetics*
Chromosome Mapping*
Chromosomes, Human, Pair 19*
Genetic Markers
Humans
Hyperlipoproteinemia Type III / blood
Hyperlipoproteinemia Type III / genetics*
Multigene Family*
Polymorphism, Restriction Fragment Length

Substances

Apolipoproteins
Genetic Markers