Cytogenetic and molecular studies of the Philadelphia translocation t(9;22) observed in a patient with myelodysplastic syndrome

N Smadja; M Krulik; A Hagemeijer; D C van der Plas; G Gonzalez Canali; A de Gramont

Cytogenetic and molecular studies of the Philadelphia translocation t(9;22) observed in a patient with myelodysplastic syndrome

Leukemia. 1989 Mar;3(3):236-8.

Authors

N Smadja¹, M Krulik, A Hagemeijer, D C van der Plas, G Gonzalez Canali, A de Gramont

Affiliation

¹ Service de Médecine Interne, Oncologie, Hôpital Saint-Antoine, Paris, France.

PMID: 2918760

Abstract

We report here the case of a patient with refractory anemia with excess of blasts (RAEB) which evolved into RAEB in transformation. The standard Philadelphia (Ph) chromosome was found by cytogenetic study at diagnosis and during evolution. Southern blot analysis showed breakpoint cluster region (bcr) rearrangement as observed in chronic myelogenous leukemia (CML).

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Anemia, Refractory, with Excess of Blasts / genetics*
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
Male
Philadelphia Chromosome*