Severe Dry Eye in CD25 Deficiency Syndrome

Eye Contact Lens. 2018 Jan;44(1):e1-e3. doi: 10.1097/ICL.0000000000000346.

Abstract

CD25 deficiency (Interleukin-2 receptor alpha deficiency) is a rare subtype of combined B- and T-cell immunodeficiency. Recurrent infections and lymphocyte infiltration of multiple tissues are the main clinical presentations. Only four patients have been reported in whom ophthalmological findings were not described. In this article, ocular findings of CD25 deficiency in a 12-year-old child are highlighted.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Conjunctiva / diagnostic imaging
  • Dry Eye Syndromes / diagnosis
  • Dry Eye Syndromes / etiology*
  • Dry Eye Syndromes / metabolism
  • Female
  • Follow-Up Studies
  • Humans
  • Immunologic Deficiency Syndromes / complications*
  • Immunologic Deficiency Syndromes / diagnosis
  • Immunologic Deficiency Syndromes / metabolism
  • Interleukin-2 Receptor alpha Subunit / deficiency*
  • Interleukin-2 Receptor alpha Subunit / metabolism*
  • Meibomian Glands / diagnostic imaging*
  • Meibomian Glands / metabolism
  • Microscopy, Acoustic
  • Severity of Illness Index

Substances

  • Interleukin-2 Receptor alpha Subunit

Supplementary concepts

  • Interleukin 2 Receptor, Alpha, Deficiency of