Sandifer syndrome

JAAPA. 2018 Apr;31(4):18-22. doi: 10.1097/01.JAA.0000531044.72598.26.

Abstract

Sandifer syndrome is a rare complication of gastroesophageal reflux disease that may be more common than reported. This syndrome was first mentioned more than 50 years ago with minimal documentation in the medical literature. Because of the presentation, the patient may be referred for lengthy, expensive, and unnecessary neurologic testing. This may lead to a missed or delayed diagnosis, mismanagement, and the use of inappropriate medication. Providers should be aware of Sandifer syndrome when evaluating a child with torticollis or unusual posturing that is not associated with neuromuscular disease or injury.

Publication types

  • Review

MeSH terms

  • Child
  • Child, Preschool
  • Diagnosis, Differential
  • Fundoplication
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / etiology
  • Gastroesophageal Reflux / physiopathology
  • Gastroesophageal Reflux / therapy*
  • Hernia, Hiatal
  • Histamine Antagonists / administration & dosage
  • Humans
  • Infant
  • Life Style
  • Posture
  • Proton Pump Inhibitors / administration & dosage
  • Seizures
  • Torticollis / diagnosis
  • Torticollis / etiology*
  • Torticollis / physiopathology
  • Torticollis / therapy*

Substances

  • Histamine Antagonists
  • Proton Pump Inhibitors

Supplementary concepts

  • Sandifer syndrome