Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

Affiliations

• ¹ Institute of Clinical and Biomedical Science, University of Exeter Medical School, RILD Building, Royal Devon & Exeter Hospital Campus, Exeter, Devon, UK.
• ² Program in Translational NeuroPsychiatric Genomics, Departments of Neurology and Psychiatry, Institute for the Neurosciences, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Neurology, Columbia University College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
• ³ Program in Translational NeuroPsychiatric Genomics, Departments of Neurology and Psychiatry, Institute for the Neurosciences, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
• ⁴ Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
• ⁵ Queen Mary University of London, London, UK.
• ⁶ Department of Psychiatry, The Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neuroscience, The Icahn School of Medicine at Mount Sinai, New York, NY, USA; JJ Peters VA Medical Center, Bronx, NY, USA.
• ⁷ Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
• ⁸ Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
• ⁹ University of Essex, Colchester, UK.
• ¹⁰ Institute of Clinical and Biomedical Science, University of Exeter Medical School, RILD Building, Royal Devon & Exeter Hospital Campus, Exeter, Devon, UK. Electronic address: j.mill@exeter.ac.uk.
• ¹¹ Institute of Clinical and Biomedical Science, University of Exeter Medical School, RILD Building, Royal Devon & Exeter Hospital Campus, Exeter, Devon, UK. Electronic address: k.lunnon@exeter.ac.uk.