Abstract
The Rpt-1 (for regulatory protein, T-lymphocyte, 1) gene, selectively expressed by resting but not by activated CD4+ inducer T cells, encodes an intracellular protein (rpt-1, Mr 41,000) that down-regulates gene expression directed by the promoter region of the gene encoding interleukin 2 receptor alpha chain and by the long terminal repeat of human immunodeficiency virus type 1. The data reported here suggest that rpt-1 levels may be inversely correlated with activation of CD4+ T cells and human immunodeficiency virus replication leading to clinical symptoms of the acquired immunodeficiency syndrome.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / physiopathology
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Line
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DNA-Binding Proteins / physiology*
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Gene Expression Regulation
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Genes
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Genes, Regulator*
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Genes, Viral
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HIV / genetics*
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Humans
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Lymphocyte Activation
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Mice
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Molecular Sequence Data
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Promoter Regions, Genetic
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Protein Conformation
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Receptors, Immunologic / genetics*
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Receptors, Interleukin-2
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T-Lymphocytes, Helper-Inducer / physiology*
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Transcription Factors / physiology*
Substances
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DNA-Binding Proteins
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Receptors, Immunologic
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Receptors, Interleukin-2
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Transcription Factors
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Trim30a protein, mouse