Histologic mimics of malignant melanoma

Singapore Med J. 2018 Nov;59(11):602-607. doi: 10.11622/smedj.2018041. Epub 2018 May 18.

Abstract

Although spongiotic (eczematous), psoriatic and cutaneous skin infections are among the most common in dermatology consultations, melanocytic lesions - including the different types of nevi and melanomas - are among those that cause a great deal of concern and stress to patients and their clinicians. A diagnosis of benign melanocytic nevus carries a very good prognosis. However, a diagnosis of melanoma might indicate more aggressive treatment, lifelong surveillance and a worse prognosis. Differentiating between these conditions is not always a straightforward process for clinicians and pathologists. Therefore, knowledge of melanoma mimickers is very important for clinicians in general, and dermatologists and pathologists in particular. In this review, we called attention to some of the more frequent benign but unusual melanocytic lesions that are of diagnostic concern for clinicians evaluating these cutaneous proliferations.

Keywords: deep penetrating nevus; dysplastic nevus; melanocytic lesions; melanoma; pigmented spindle cell nevus.

Publication types

  • Review

MeSH terms

  • Cell Proliferation
  • Diagnosis, Differential
  • Humans
  • Incidence
  • Melanoma / diagnosis*
  • Melanoma / epidemiology
  • Melanoma / pathology
  • Melanoma, Cutaneous Malignant
  • Nevus, Pigmented / diagnosis*
  • Nevus, Pigmented / epidemiology
  • Nevus, Pigmented / pathology
  • Prognosis
  • Risk
  • Skin / pathology
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / pathology
  • United States