Alpha globin gene rearrangements in Polynesians are not associated with malaria

Am J Hematol. 1985 Apr;18(4):431-3. doi: 10.1002/ajh.2830180414.

Abstract

Using gene mapping, 16.3% of Polynesians were shown to have alpha thalassemia. These results are surprising since malaria is not found in Polynesia. Moreover, triplicated alpha gene rearrangements were identified in a further 7.7%, a frequency not seen in other populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping*
  • DNA Restriction Enzymes
  • Fetal Blood / analysis
  • Genotype
  • Globins / genetics*
  • Humans
  • Malaria / blood
  • Malaria / genetics*
  • Polynesia
  • Thalassemia / genetics

Substances

  • Globins
  • DNA Restriction Enzymes