Evidence against close linkage of the loci for fraXq of Martin-Bell syndrome and for factor IX

B Zoll; J Arnemann; M Krawczak; D N Cooper; G Pescia; W Wahli; P Steinbach; J Schmidtke

doi:10.1007/BF00283366

Evidence against close linkage of the loci for fraXq of Martin-Bell syndrome and for factor IX

Hum Genet. 1985;71(2):122-6. doi: 10.1007/BF00283366.

Authors

B Zoll, J Arnemann, M Krawczak, D N Cooper, G Pescia, W Wahli, P Steinbach, J Schmidtke

PMID: 2995232
DOI: 10.1007/BF00283366

Abstract

Linkage between the loci for fraXq of Martin-Bell syndrome and factor IX was studied in nine families exhibiting this syndrome by means of a restriction fragment length polymorphism at the factor IX locus. Computer analysis of the data indicates there to be no evidence for close linkage between the syndrome and the factor IX locus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Fragility*
Chromosome Mapping
DNA Restriction Enzymes
Deoxyribonucleases, Type II Site-Specific*
Electrophoresis, Agar Gel
Factor IX / genetics*
Female
Genetic Linkage*
Genetic Markers
Humans
Intellectual Disability / genetics*
Male
Pedigree
Syndrome
X Chromosome*

Substances

Genetic Markers
Factor IX
DNA Restriction Enzymes
Deoxyribonucleases, Type II Site-Specific
TCGA-specific type II deoxyribonucleases