Abstract
A DNA sequence polymorphism, revealed by digestion of human DNA with the restriction endonuclease Sst-1 and hybridization with an apolipoprotein A-I complementary DNA clone, has been shown to be located in or close to the 3' noncoding region of the apolipoprotein C-III gene. This polymorphism is found in significantly increased prevalence (P less than 0.001) in Caucasian hypertriglyceridemic subjects compared with race-matched controls, and its distribution in normal individuals of differing racial origins is reported. Furthermore, no alteration of high density lipoprotein or apolipoprotein A-I and apolipoprotein C-III phenotypes was observed in individuals with or without the polymorphism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Apolipoprotein A-I
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Apolipoprotein C-III
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Apolipoproteins A / blood
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Apolipoproteins A / genetics*
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Apolipoproteins C / blood
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Apolipoproteins C / genetics*
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Child
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China / ethnology
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DNA / genetics*
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DNA Restriction Enzymes / metabolism
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Deoxyribonucleases, Type II Site-Specific*
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Female
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Genes*
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Genotype
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Humans
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Hyperlipoproteinemia Type IV / genetics*
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Isoelectric Focusing
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Lipoproteins, HDL / blood
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Male
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Pedigree
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Polymorphism, Genetic*
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White People
Substances
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Apolipoprotein A-I
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Apolipoprotein C-III
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Apolipoproteins A
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Apolipoproteins C
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Lipoproteins, HDL
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DNA
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DNA Restriction Enzymes
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endodeoxyribonuclease SacI
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Deoxyribonucleases, Type II Site-Specific