The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias

Proc Natl Acad Sci U S A. 1986 Mar;83(5):1403-7. doi: 10.1073/pnas.83.5.1403.

Abstract

Genomic and cDNA clones for the human nerve growth factor receptor have been used in conjunction with somatic cell hybrid analysis and in situ hybridization to localize the nerve growth factor receptor locus to human chromosome region 17q12-q22. Additionally, part, if not all, of the nerve growth factor receptor locus is present on the translocated portion of 17q (17q21-qter) from a poorly differentiated acute leukemia in which the chromosome 17 breakpoint was indistinguishable cytogenetically from the 17 breakpoint observed in the t(15;17)(q22;q21) translocation associated with acute promyelocytic leukemia. Thus the nerve growth factor receptor locus may be closely distal to the acute promyelocytic leukemia-associated chromosome 17 breakpoint at 17q21.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, 16-18*
  • Genetic Linkage
  • Humans
  • Hybrid Cells / physiology
  • Leukemia, Myeloid, Acute / genetics
  • Nerve Growth Factors*
  • Nucleic Acid Hybridization
  • Receptors, Cell Surface / genetics*
  • Receptors, Nerve Growth Factor
  • Translocation, Genetic

Substances

  • Nerve Growth Factors
  • Receptors, Cell Surface
  • Receptors, Nerve Growth Factor