Abstract
Anterior pituitaries from the dwarf mouse strain "little" did not release growth hormone or accumulate adenosine 3',5'-monophosphate (cyclic AMP) in response to human and rat growth hormone-releasing factor (GRF). Dibutyryl cyclic AMP, as well as the adenylate cyclase stimulators forskolin and cholera toxin, markedly stimulated growth hormone (GH) release. The basis of the GH deficiency in the little mouse may therefore be a defect in an early stage of GRF-stimulated GH release related either to receptor binding or to the function of the hormone-receptor complex.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Colforsin / pharmacology
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Cyclic AMP / analysis
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Dwarfism, Pituitary / physiopathology*
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Female
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Growth Hormone-Releasing Hormone / metabolism
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Growth Hormone-Releasing Hormone / pharmacology
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Growth Hormone-Releasing Hormone / physiology
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Humans
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Mice
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Mice, Inbred C57BL
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Mice, Mutant Strains / physiology*
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Pituitary Gland, Anterior / analysis
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Pituitary Gland, Anterior / drug effects
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Pituitary Gland, Anterior / metabolism
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Pituitary Gland, Anterior / physiopathology
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Receptors, Cell Surface / metabolism
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Receptors, Cell Surface / physiology*
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Receptors, Neuropeptide*
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Receptors, Pituitary Hormone-Regulating Hormone*
Substances
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Receptors, Cell Surface
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Receptors, Neuropeptide
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Receptors, Pituitary Hormone-Regulating Hormone
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Colforsin
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Growth Hormone-Releasing Hormone
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Cyclic AMP
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somatotropin releasing hormone receptor