Abstract
Neuroleukin is a lymphokine product of lectin-stimulated T cells that induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells. Neuroleukin acts early in the in vitro response that leads to formation of antibody-secreting cells, but continued production of immunoglobulin by differentiated antibody-secreting cells is neuroleukin-independent. Although the factor is not directly mitogenic, cellular proliferation is a late component of the response to neuroleukin. Neuroleukin does not have B-cell growth factor (BCGF) or B-cell differentiation factor (BCDF) activity in defined assays. Neuroleukin-evoked induction of immunoglobulin secretion is both monocyte- and T-cell-dependent.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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B-Lymphocytes / drug effects
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B-Lymphocytes / physiology
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Bone Marrow / metabolism
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Cell Line
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Cells, Cultured
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Deltaretrovirus / genetics
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Glucose-6-Phosphate Isomerase
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Growth Substances / genetics
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Growth Substances / pharmacology
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Growth Substances / physiology*
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Humans
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Immunity, Cellular / drug effects
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Immunoglobulins / biosynthesis
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Lectins / pharmacology
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Leukemia / metabolism
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Lymphokines / genetics
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Lymphokines / pharmacology
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Lymphokines / physiology*
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Lymphoma / metabolism
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Mice
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Pokeweed Mitogens / pharmacology
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Sequence Homology, Nucleic Acid
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T-Lymphocytes / drug effects
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T-Lymphocytes / physiology*
Substances
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Growth Substances
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Immunoglobulins
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Lectins
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Lymphokines
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Pokeweed Mitogens
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Glucose-6-Phosphate Isomerase