Abstract
Oncogene expression was examined in the human fetal liver and human hepatomas. Erb (B), erb (A+B), Ha-ras, myc, fos and fms oncogene expression elevated in certain stages of fetal liver development and in hepatoma as compared to the normal adult human liver. In contrast, rel, src, mos, sis, myb, Ki-ras and bas oncogenes showed no apparent change of their mRNA levels during fetal liver development and in hepatoma. Further study of erb B oncogene expression in human cirrhotic liver and hepatoma demonstrated a strong correlation between erb B expression and alteration of its gene structure.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Carcinoma, Hepatocellular / genetics*
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Cell Division
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DNA-Binding Proteins / genetics
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GTP Phosphohydrolases / genetics
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Gene Expression Regulation
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Gestational Age
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Growth Substances / genetics
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Humans
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Liver / embryology*
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Liver / metabolism
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Liver Cirrhosis / genetics
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Liver Neoplasms / genetics*
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Nucleic Acid Hybridization
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Oncogenes*
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Protein Kinases / genetics
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RNA, Messenger / metabolism
Substances
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DNA-Binding Proteins
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Growth Substances
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RNA, Messenger
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Protein Kinases
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GTP Phosphohydrolases