Amplification of the c-myc gene and the elevation of its transcripts in human ovarian tumor lines

Cell Struct Funct. 1987 Feb;12(1):121-5. doi: 10.1247/csf.12.121.

Abstract

c-myc gene was amplified in the human ovarian tumor line OS-4 5-6-fold and in the OvCa-1 line 3-4-fold. The relative amount of the transcript from the c-myc gene to the total RNA in OS-4 was 6-fold that for normal cells.

MeSH terms

  • Cell Line
  • DNA Restriction Enzymes
  • DNA, Neoplasm / genetics*
  • Female
  • Gene Amplification
  • Gene Expression Regulation
  • Humans
  • Ovarian Neoplasms / genetics*
  • Proto-Oncogenes*
  • RNA, Messenger / genetics
  • RNA, Neoplasm / genetics
  • Transcription, Genetic

Substances

  • DNA, Neoplasm
  • RNA, Messenger
  • RNA, Neoplasm
  • DNA Restriction Enzymes