Abstract
Seven testicular tumours of different histological type--two seminomas, two teratomas/teratocarcinomas/embryonal carcinomas, one mixed seminoma/teratoma, one Leydig cell tumour and one testicular lymphoma--were examined for the expression of four potentially growth regulatory genes by Northern blotting. Seven out of seven testicular tumours contained transcripts that hybridized with a human insulin cDNA-probe whereas only four out of seven tumours contained IGF II transcripts. One tumour contained high levels of LDL-receptor transcript whereas all seven tumours contained significant quantities of HMG-CoA-reductase mRNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA / metabolism
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Dysgerminoma / genetics
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Dysgerminoma / metabolism
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Genes
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Genes, Regulator*
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Humans
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Hydroxymethylglutaryl CoA Reductases / genetics
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Insulin / genetics
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Insulin-Like Growth Factor II / genetics
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Male
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Neoplasms, Germ Cell and Embryonal / genetics*
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Neoplasms, Germ Cell and Embryonal / metabolism
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RNA, Neoplasm / isolation & purification
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Receptors, LDL / genetics
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Teratoma / genetics
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Teratoma / metabolism
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Testicular Neoplasms / genetics*
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Testicular Neoplasms / metabolism
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Transcription, Genetic*
Substances
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Insulin
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RNA, Neoplasm
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Receptors, LDL
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Insulin-Like Growth Factor II
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DNA
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Hydroxymethylglutaryl CoA Reductases