Abstract
We studied reception of sex steroid hormones in the tissues of thyroid papillary cancer and benign tumor. Enhanced expression of AR and ERβ mRNA reflected malignant tumor growth. Nuclear factors Brn-3α and TRIM16 modulating expression of steroid hormones play an important role in the development of thyroid tumors. It was found that the level of TRIM16 mRNA is associated with the expression of ERβ, which seems to be mediated by its antiestrogen effect.
Keywords:
AR; Brn-3α; ER; TRIM16; thyroid cancer.
MeSH terms
-
Adult
-
Aged
-
Case-Control Studies
-
DNA-Binding Proteins / genetics*
-
DNA-Binding Proteins / metabolism
-
Estrogen Receptor beta / genetics*
-
Estrogen Receptor beta / metabolism
-
Female
-
Gene Expression Regulation, Neoplastic*
-
Humans
-
Male
-
Middle Aged
-
Neoplasms / genetics
-
Neoplasms / metabolism
-
Neoplasms / pathology
-
RNA, Messenger / genetics
-
RNA, Messenger / metabolism
-
Receptors, Androgen / genetics*
-
Receptors, Androgen / metabolism
-
Signal Transduction
-
Thyroid Cancer, Papillary / genetics*
-
Thyroid Cancer, Papillary / metabolism
-
Thyroid Cancer, Papillary / pathology
-
Thyroid Gland / metabolism
-
Thyroid Gland / pathology
-
Thyroid Neoplasms / genetics*
-
Thyroid Neoplasms / metabolism
-
Thyroid Neoplasms / pathology
-
Transcription Factor Brn-3A / genetics*
-
Transcription Factor Brn-3A / metabolism
-
Transcription Factors / genetics*
-
Transcription Factors / metabolism
-
Tripartite Motif Proteins
-
Ubiquitin-Protein Ligases
Substances
-
AR protein, human
-
DNA-Binding Proteins
-
ESR2 protein, human
-
Estrogen Receptor beta
-
RNA, Messenger
-
Receptors, Androgen
-
Transcription Factor Brn-3A
-
Transcription Factors
-
Tripartite Motif Proteins
-
TRIM16 protein, human
-
Ubiquitin-Protein Ligases