Treatment and prognosis of mature (non-anaplastic) T- and NK-cell lymphomas in childhood, adolescents, and young adults

Br J Haematol. 2019 Jun;185(6):1086-1098. doi: 10.1111/bjh.15772. Epub 2019 Feb 1.

Abstract

Paediatric non-Hodgkin lymphomas (pNHL) are a diverse group of malignancies characterised by nodal and/or extranodal involvement. Less common pNHL forms include those derived from mature T- and natural killer (NK) cells. Much of our current understanding of paediatric mature (non-anaplastic) T/NK-cell lymphomas with respect to pathogenesis, diagnosis and treatment is extrapolated from adult literature. At the Sixth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma, convened September 26-29, 2018 in Rotterdam, The Netherlands, some important aspects on diagnosis and outcomes of mature (non-anaplastic) T/NK-cell lymphoma in children and adolescents were discussed and will be reviewed in here.

Keywords: extranodal NK-T-cell lymphoma; non-Hodgkin lymphoma; paediatrics; peripheral T-cell lymphoma; stem cell transplantation.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Child
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Disease Management
  • Disease Susceptibility
  • Female
  • Humans
  • Lymphoma, Extranodal NK-T-Cell / diagnosis*
  • Lymphoma, Extranodal NK-T-Cell / etiology
  • Lymphoma, Extranodal NK-T-Cell / mortality
  • Lymphoma, Extranodal NK-T-Cell / therapy*
  • Male
  • Neoplasm Grading
  • Prognosis
  • Treatment Outcome
  • Young Adult