Cardiac Resynchronization Therapy in Preserved to Mildly Reduced Systolic Function

Chance M Witt; Yong-Mei Cha

doi:10.1016/j.ccep.2018.11.012

Cardiac Resynchronization Therapy in Preserved to Mildly Reduced Systolic Function

Card Electrophysiol Clin. 2019 Mar;11(1):141-146. doi: 10.1016/j.ccep.2018.11.012. Epub 2018 Dec 24.

Authors

Chance M Witt¹, Yong-Mei Cha²

Affiliations

¹ Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
² Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: ycha@mayo.edu.

PMID: 30717846
DOI: 10.1016/j.ccep.2018.11.012

Abstract

Cardiac resynchronization therapy has been proven to be clearly beneficial for patients with heart failure, a prolonged QRS duration, and a left ventricular ejection fraction ≤35%. Ejection fraction cutoff, however, is arbitrary and very likely excludes many patients who could benefit from cardiac resynchronization. This article describes the major detrimental effects of left bundle branch block and summarizes the data regarding the potential beneficial effects of cardiac resynchronization in patients with a left ventricular ejection fraction greater than 35%.

Keywords: Cardiac resynchronization therapy; Heart failure with preserved ejection fraction; Heart failure with reduced ejection fraction.

Publication types

Review

MeSH terms

Bundle-Branch Block
Cardiac Resynchronization Therapy*
Heart Failure, Systolic / therapy*
Humans
Prospective Studies
Stroke Volume