Abstract
Twenty-five patients with rheumatoid arthritis (RA) who developed toxicity while taking remission inducing drugs and 30 without toxicity were studied for possible associations with class I and II HLA antigens. A strong association has been found between nephritis and dermatitis due to Tiopronin (a D-Penicillamine like compound) and class I antigens B35-Cw4, and between dermatitis due to gold thiosulphate and B35. Compared to healthy controls a lower DR5 frequency was observed in patients with RA except for the Tiopronin related nephritis group.
MeSH terms
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Adult
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Aged
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Amino Acids, Sulfur / adverse effects*
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Arthritis, Rheumatoid / drug therapy
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Arthritis, Rheumatoid / immunology*
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Dermatitis / chemically induced
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Female
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Gold / adverse effects*
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Gold / therapeutic use
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Gold Sodium Thiosulfate / adverse effects*
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Gold Sodium Thiosulfate / therapeutic use
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HLA Antigens / analysis*
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HLA-B35 Antigen
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HLA-C Antigens*
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Humans
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Male
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Middle Aged
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Nephritis / chemically induced
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Thrombocytopenia / chemically induced
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Tiopronin / adverse effects*
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Tiopronin / therapeutic use
Substances
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Amino Acids, Sulfur
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HLA Antigens
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HLA-B35 Antigen
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HLA-C Antigens
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HLA-C*04 antigen
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Gold
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Tiopronin
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Gold Sodium Thiosulfate