Expression and prognostic significance of MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) in ESCC tissues

Lina Gu; Meixiang Sang; Juan Li; Fei Liu; Yunyan Wu; Shina Liu; Pengyu Wang; Baoen Shan

doi:10.1016/j.prp.2019.152446

Expression and prognostic significance of MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) in ESCC tissues

Pathol Res Pract. 2019 Jul;215(7):152446. doi: 10.1016/j.prp.2019.152446. Epub 2019 May 8.

Authors

Lina Gu¹, Meixiang Sang², Juan Li¹, Fei Liu¹, Yunyan Wu¹, Shina Liu¹, Pengyu Wang¹, Baoen Shan³

Affiliations

¹ Department of Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
² Department of Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China; Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. Electronic address: mxsang@hotmail.com.
³ Department of Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China; Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. Electronic address: baoenshan@hotmail.com.

PMID: 31126819
DOI: 10.1016/j.prp.2019.152446

Abstract

Objective: To evaluate the clinical characteristics and prognostic significance of MAGE-A11 and transcription factors (SP1, TFCP2 and ZEB1) in patients with esophageal squamous cell carcinoma (ESCC).

Methods: To assess the expression of MAGE-A11 and transcription factors (SP1, TFCP2 and ZEB1) in 121 ESCC samples were respectively detected by immunohistochemical method.

Results: The results showed MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) expression were associated with some clinical features in patients, such as pathological differentiation, tumor size, clinical stage, lymph node metastasis and distant metastasis. Kaplan-Meier analysis showed that patients with ESCC having high MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) expression had a worse prognosis compared to the patients with low expression. Multivariate Cox proportional hazards regression model revealed that MAGE-A11 expression, TFCP2 expression, lymph node metastasis and distant metastasis were independently associated with ESCC patients' survival.

Conclusions: High expression of MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) in ESCC tissues suggests promoting ESCC progression and poor prognosis, co-expression of MAGE-A11 and transcription factors even worse.

Keywords: ESCC; Expression; MAGE-A11; Prognosis; SP1,TFCP2, ZEB1.

MeSH terms

Antigens, Neoplasm / metabolism*
Carcinoma, Squamous Cell / metabolism*
Carcinoma, Squamous Cell / mortality
Carcinoma, Squamous Cell / pathology
DNA-Binding Proteins / metabolism*
Esophageal Neoplasms / metabolism*
Esophageal Neoplasms / mortality
Esophageal Neoplasms / pathology
Humans
Lymphatic Metastasis
Middle Aged
Neoplasm Proteins / metabolism*
Neoplasm Staging
Sp1 Transcription Factor / metabolism*
Survival Rate
Transcription Factors / metabolism*
Zinc Finger E-box-Binding Homeobox 1 / metabolism*

Substances

Antigens, Neoplasm
DNA-Binding Proteins
MAGEA11 protein, human
Neoplasm Proteins
Sp1 Transcription Factor
SP1 protein, human
TFCP2 protein, human
Transcription Factors
ZEB1 protein, human
Zinc Finger E-box-Binding Homeobox 1