Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier

Johannes A Rijken; Berry de Vos; C René Leemans; G J C Ben Zwezerijnen; Pim de Graaf; Erik F Hensen; Koen M A Dreijerink; Chris Dickhoff; Petr Symersky

doi:10.1016/j.athoracsur.2019.05.037

Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier

Ann Thorac Surg. 2020 Feb;109(2):e87-e90. doi: 10.1016/j.athoracsur.2019.05.037. Epub 2019 Jul 4.

Authors

Johannes A Rijken¹, Berry de Vos², C René Leemans², G J C Ben Zwezerijnen³, Pim de Graaf³, Erik F Hensen⁴, Koen M A Dreijerink⁵, Chris Dickhoff⁶, Petr Symersky⁷

Affiliations

¹ Department of Otolaryngology/Head and Neck Surgery, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands. Electronic address: johannesrijken@hotmail.com.
² Department of Otolaryngology/Head and Neck Surgery, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands.
³ Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands.
⁴ Department of Otolaryngology/Head and Neck Surgery, Leiden University Medical Center, Leiden, the Netherlands.
⁵ Department of Endocrinology, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands.
⁶ Department of Surgery, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
⁷ Department of Cardiothoracic Surgery, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands.

PMID: 31279790
DOI: 10.1016/j.athoracsur.2019.05.037

Abstract

Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed against the risks of treatment complications. We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of 3 paragangliomas in a SDHD mutation carrier.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
DNA Mutational Analysis
DNA, Neoplasm / genetics*
Head and Neck Neoplasms / diagnosis
Head and Neck Neoplasms / genetics*
Head and Neck Neoplasms / metabolism
Humans
Magnetic Resonance Imaging
Male
Mutation*
Neoplasms, Multiple Primary / diagnosis
Neoplasms, Multiple Primary / genetics*
Neoplasms, Multiple Primary / metabolism
Neoplastic Syndromes, Hereditary / diagnosis
Neoplastic Syndromes, Hereditary / genetics
Neoplastic Syndromes, Hereditary / metabolism
Paraganglioma / diagnosis
Paraganglioma / genetics
Paraganglioma / metabolism
Positron Emission Tomography Computed Tomography
Succinate Dehydrogenase / genetics*
Succinate Dehydrogenase / metabolism
Thoracic Neoplasms / diagnosis
Thoracic Neoplasms / genetics*
Thoracic Neoplasms / metabolism

Substances

DNA, Neoplasm
SDHD protein, human
Succinate Dehydrogenase

Supplementary concepts

Paragangliomas 3