The simian crease: Relationship to various genetic disorders

The creases of the palm have been of interest for clinicians, anthropologists, and palmists for hundreds of years, but the variations in them have only been studied during the past 50 years. The simian crease, aptly named for its resemblance to the palmar creases of nonhuman simian primates, has received recognition clinically and anthropologically owing to its abnormal appearance and confounding cytogenetic etiology. Given the rarity of these palmar creases but also their usefulness in diagnosing congenital disorders, discussion of cases of those disorders could provide clinicians with further helpful diagnostic knowledge. This review of the literature focuses on the history, embryology, genetic and hereditary origins, and clinical significance of simian creases for the benefit of the diagnosing clinician. Clin. Anat. 32:1042-1047, 2019. © 2019 Wiley Periodicals, Inc.